About us
Who we are
CardioDynamics and Intelligence is a medical technology company based in Chicago. It brings together interventional cardiologists, physician-scientists and engineers around one question: how does the movement of blood shape heart disease, and how can we measure it well enough to act on it?
The company grew out of nearly three decades of clinical research and teaching in interventional cardiology, and a long-running program on coronary flow built on hydraulics, acoustics and frame-by-frame angiography. We are turning that program into AI algorithms and medical devices.
Founder & CEO
John M. Le, MD, PhD
Physician-scientist
Dr. Le works on large language models, computer vision, machine learning and deep learning applied to cardiology and multimodal imaging — ECG, echocardiography, CT, MRI and digital subtraction angiography — with a focus on clinically deployable AI systems for diagnosis, risk stratification and clinical decision support.
He has led collaborative AI projects with researchers at Harvard Medical School, Johns Hopkins University and Carnegie Mellon University on real-time imaging interpretation and cardiovascular phenotyping. His work has appeared in The Lancet, NEJM, JAMA, EClinicalMedicine, Briefings in Bioinformatics and the IEEE Journal of Biomedical and Health Informatics, with presentations at AHA Scientific Sessions, ACC's Annual Scientific Session, IEEE EMBS, ISBI, ICCV and MICCAI.
Manager · Management Committee
Loc Vu, MD, FACC, FAHA
Cardiologist and Clinical Lecturer, Vietnam
Dr. Vu's research focuses on coronary artery disease — coronary physiology, flow dynamics, and artificial intelligence in cardiovascular imaging. He collaborates on the Global Burden of Disease study at the University of Washington Institute for Health Metrics and Evaluation, and reviews abstracts for the American College of Cardiology Quality Summit and the American Heart Association's Cardiomyopathies Peer Review Committee.
He completed the Global Clinical Scholars Research Training certificate program at Harvard Medical School (2025) and received the Paul Dudley White International Scholar Award at the 2023 AHA Scientific Sessions for the highest-scoring abstract from Vietnam. He serves on the Communications Committee of the AHA's Council on Clinical Cardiology, is a Social Media Ambassador for the Cardiovascular Research Foundation in Seoul, and is a participant in the 2026 cohort of the International Atherosclerosis Society's Inflammation Academy.
"The program gave me far more than just research skills," he says of his time at Harvard. "It changed the way I ask scientific questions, collaborate across cultures, communicate evidence, and think about leadership."
TNThach N. Nguyen, MD
Interventional cardiologist · FACC, FSCAI
Dr. Nguyen has spent nearly three decades teaching and studying interventional cardiology. He is lead editor of the Practical Handbook of Advanced Interventional Cardiology: Tips and Tricks, now in its 6th edition (Wiley, 2026), and of Management of Complex Cardiovascular Problems, and has authored more than 180 indexed publications since 1998.
He served on the Board of Trustees of the Society for Cardiovascular Angiography and Interventions (SCAI, 2013–2016), has helped organize the Great Wall International Congress of Cardiology since 1992, and is an honorary professor of medicine at Hanoi Medical University. He originated dynamic coronary angiography and the coronary acoustic map.
CGProf. C. Michael Gibson
Professor of Medicine, Harvard Medical School · MS, MD
Prof. Gibson is an interventional cardiologist at Beth Israel Deaconess Medical Center and chief executive of the Baim Institute for Clinical Research and the PERFUSE Study Group, which he founded in 1987. He invented the TIMI frame count and the TIMI myocardial perfusion grade, angiographic measures of coronary blood flow now used worldwide.
The institutes he leads have run more than 1,000 studies across a network of thousands of sites, and he has repeatedly been named among the most highly cited researchers in science.
